A preventive immunization approach against insect bite hypersensitivity: Intralymphatic injection with recombinant allergens in Alum or Alum and monophosphoryl lipid A

Nitrate removal from water using alum and ferric chloride: A comparative study of alum and ferric chloride efficiency

Background: Nitrate is an acute and well-known hazardous contaminant, and its contamination of water sources has been a growing concern worldwide in recent years. This study evaluated the feasibility of nitrate removal from water using the traditional coagulants alum and ferric chloride with lower concentrations than those used in the conventional coagulation process. Methods: In this research...

Vaccination with toxofilin DNA in combination with an alum-monophosphoryl lipid A mixed adjuvant induces significant protective immunity against Toxoplasma gondii

BACKGROUND A widely prevalent disease, toxoplasmosis poses serious health threats to both humans and animals; therefore, development of an ideal DNA vaccine against Toxoplasma gondii is needed eagerly. The purpose of the present study is to assess the protective efficacy of a DNA vaccine encoding the T. gondii toxofilin gene (pEGFP-toxofilin). In addition, toxofilin DNA vaccine combined with th...

Alum Coagulation

Efficacy and safety of rush immunotherapy with alum-precipitated allergens in canine atopic dermatitis.

OBJECTIVES Canine atopic dermatitis is a very common disease in small animal practice. Its only specific treatment is allergen immunotherapy. In rush-immunotherapy (RIT) increasing doses of allergen extract are injected subcutaneously in short intervals. Maintenance doses are achieved within one day compared to weeks or months with conventional immunotherapy. The aim of this study was to evalua...

How alum works

For more than 70 years, alum has been used as a trusty aide to improve antibody responses to vaccines. But how this aluminum-containing compound boosts the response to vaccines has been a mystery. On page 869, Kool et al. expose its mysterious mechanism; they find that alum causes cells to produce a stim-ulator of dendritic cells (DCs). DCs were once the favored hypothetical link between alum a...